Friday, May 31st 2013

Feedback Loops: The Biology and Culture of Premenstrual Experience

I think my umbilical hernia is getting bigger. I’ve had it since my pregnancy over five years ago, the result of diastasis, a situation where the abdominal muscles pull apart from the baby taking up so much darn room. I’ve consulted with a surgeon, and the hernia is tiny, not worth fixing until I’m done childbearing since having another kid would likely open it up again.

But despite a medical professional’s blessing and my own research, I’m staring at this hernia. I think it’s bigger. Or maybe I’m just bloated. Maybe I’m lactose intolerant. Or I ate something contaminated with gluten. Maybe I’m experiencing strangulation of my intestines, right now, and I should be calling the doctor or going to the ER. How long do I have? Could I pass out before getting there? Will my intestines rupture? What if they have to do surgery on me?

How many weeks will I have to stay off my skates?

My brain does this most premenstrual phases over the last year. For three to four days I become a semi-depressed hypochondriac. Because I now recognize that these thoughts increase premenstrually, I’m able to laugh about it a bit, and I’m able to set them aside by telling myself that if I feel the same way in a week, I’ll go to the doctor.

I haven’t needed to go to the doctor.

I don’t know why my premenstrual experience is like this, not exactly. It seems to be context-dependent, because it relates to one of my big fears – getting sick in a way that could derail my busy lifestyle, keep me from doing my job, make me neglect my child, or force me from my sport.

To me, being sick means letting other people down.


Culture- and experience-bound illness

Our illnesses, worries and feelings are all culture- and experience-bound. But alongside illnesses that appear only in certain contexts are very real, physiological phenomena that are influenced by both biology and culture. The two are not mutually exclusive.

I was motivated to write this post because Amanda Marcotte, someone I greatly admire, wrote a piece earlier this week about premenstrual syndrome (PMS) as a culture-bound syndrome. There, Marcotte points to work suggesting that the origin of PMS is in our culture, not our biology, even adding that PMS “panders” to the idea that women are overemotional. She quotes from researchers who discuss women who are “highly resistant” to evidence that PMS is culturally bound, who find PMS “convenient” as an excuse for bad behavior in order to hold on to notions of themselves as good women.

PMS is surely a culture-bound syndrome. However, Marcotte seems to imply that PMS’s cultural origin negates the possibility of there also being a biological or physiological component to PMS, and this is not the case. The definition of a culture-bound syndrome is a cluster of symptoms that appears different among different cultures. The symptoms being bounded by different cultural expectations of how they should manifest doesn’t mean there couldn’t, in some cases, be a biological component as well. There are many physical phenomena that we experience differently based on our culture, but that doesn’t mean the underlying issue isn’t real. Even the way a person responds to a stubbed toe is going to be highly dependent on that culture’s perception of pain, machismo, and a host of other culture- and gender-bound expectations.

We all still stub our toes.


PMS is not universal, but…

All people who have menstrual cycles have a premenstrual phase and thus premenstrual experiences. For some of those people, you can’t identify a difference between the experiences of the premenstrual phase from any other time in her cycle. For others, there is a cluster of symptoms linked to that time period. The biggest problem about the way in which PMS is embedded in our culture, to my mind, is the way it’s situated as a universal and universally negative. The only aspect of premenstrual experience that should be explicitly pathologized is anything that disrupts normal functioning. This is why we have the additional classification of premenstrual dysphoric disorder, or PMDD. Using the criteria of PMDD only 8-10% of reproductively-aged women fall into this category.

As it turns out, there is an enormous literature on the hormonal factors that may explain PMDD. And some of it may even shed light on why there is cultural variation in premenstrual experiences that make it seem as though western women overexpress negative symptoms.

One of the main mechanisms of PMDD is related to progesterone withdrawal. Mouse study after mouse study has shown that if you give a mouse a ton of progesterone, then wait a little bit, that withdrawal period is a time when the mice become depressed. If you hold them up by their tail, they don’t struggle. If you try to get them to swim, they give up (don’t worry, that doesn’t mean they drown, only float). The mechanism is related to the way in which the withdrawal of progesterone (and thus its neuroactive metabolite allopregnanolone) influences GABA receptors in the brain.

Now, all ovulatory cycles should have a midluteal (that’s about three quarters of the way through a menstrual cycle) peak of progesterone, followed by progesterone withdrawal. But not all ovulatory cycles lead to those women experiencing PMDD. What is explaining this variation in experience?

There is growing evidence that women have varying sensitivity to the hormones they produce, such that two could have the same hormone concentrations but one could have a more acute experience from progesterone withdrawal. But the other important factor here, is that because we have a lifestyle that leads to eating more and being less active than most, western, industrialized women have the highest progesterone of all women globally.

So rather than seeing this cultural variation as entirely a product of the culture-bound syndrome, we can also see that it has to do with the ways in which western women are at the farthest end of the spectrum in terms of actual hormone concentrations. We have the highest hormones, so we have the furthest to fall. Our experience of progesterone withdrawal is more frequent and more extreme than probably any other human population on the planet.


Biocultural approaches to the premenstrual experience

Therefore, there is both a cultural and biological component to the premenstrual experience that makes western women more likely to experience clusters of negative symptoms during this phase. I think it’s worth noticing the many important feminist contributions to our understanding of PMS and premenstrual experiences. These critiques of cultural norms that limit women’s expression have done a good job making sure that medicine better bounds the definition of PMDD, rather than pathologize all women.

At the same time, these cultural constructions need to be viewed alongside the equally important evidence that the frequent cycles and steep progesterone withdrawal produced by our energy surplus environment, individual variation in sensitivity, and individual variation in other important contexts are going to lead to diverse experiences of the premenstrual phase. Because these symptoms (positive and negative) can manifest so differently for different women, it makes sense that meta-analyses like the one Marcotte cites did not find a relationship between the premenstrual phase and low mood.

Western women live in a culture that promotes overwork; Emily Martin has pointed out that experiences of PMS may be a result of women chafing against flaws in our culture, rather than PMS representing a flaw in our bodies (1980). And so again we can see not that culture and biology are disparate, but that they can influence each other: overwork can contribute to consumption of energy-dense food and low physical activity, which drives progesterone concentrations up, which makes that withdrawal curve so steep.

In the end, it doesn’t make sense to view the biology and culture of premenstrual experiences separately. Biology and culture aren’t two sides of a coin, but the two massive and overlapping components of the feedback loop that helps us understand human motivations, behaviors, and physiology.



Martin E. 1980. The Woman in the Body: A Cultural Analysis of Reproduction. Boston: Beacon Press.


Addendum (6/1/13, 10pm CST)

I realized I should have provided some citations for the relationship between progesterone and mood. Here are a handful of papers that folks may find interesting:

Beckley, E. H. and D. A. Finn (2007). “Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility.” Pharmacology, Biochemistry and Behavior 87: 412-419.

Brinton, R. D., R. F. Thompson, et al. (2008). “Progesterone receptors: Form and function in brain.” Frontiers in Neuroendocrinology 29(2): 313-339.

Dantzer, R. and K. W. Kelley (2007). “Twenty years of research on cytokine-induced sickness behavior.” Brain, Behavior, and Immunity 21(2): 153-160.

Espallergues, J., L. Givalois, et al. (2009). “The 3[beta]-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice.” Psychoneuroendocrinology 34(5): 644-659.

Frye, C. A., A. A. Walf, et al. (2004). “Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5[alpha]-reductase.” Brain Research 1004(1-2): 116-124.

Reed, S. C., F. R. Levin, et al. (2008). “Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder).” Hormones and Behavior 54(1): 185-193.

Sulak, P. J., R. D. Scow, et al. (2000). “Hormone Withdrawal Symptoms in Oral Contraceptive Users.” Obstetrics & Gynecology 95(2): 261-266.

1 Comment

  1. PMS | Piškotarna said:

    […] Clancy, ameriška biološka antropologinja, v zapisu o biologiji in kulturi pri predmenstrualni izkušnji, piše o miših, ki so jim najprej dodali progesteron in jim ga nato odvzeli, opazimo nenavadna […]

Sorry, the comment form is closed at this time.